Structure of PDB 8gzr Chain B Binding Site BS01

Receptor Information
>8gzr Chain B (length=443) Species: 12637 (Dengue virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PELEEEMFKKRNLTIMDLHPGSGKTRKYLPAIVREAIKRRLRTLILAPTR
VVAAEMEEALKGLPIRYQTTATKSEHTGKEIVDLMCHATFTMRLLSPVRV
PNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAF
PQSNAPIQDEERDIPERSWNSGNDWITDFAGKTVWFVPSIKAGNDIANCL
RKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDP
RRCLKPVILTDGPERVILAGPMPVTVASAAQRRGRVGRNPQKENDQYIFT
GQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRL
KGESRKTFVELMRRGDLPVWLAHKVASEGIKYTDRKWCFDGERNNQILEE
NMDVEIWTKEGEKKKLRPRWLDARTYSDPLALKEFKDFAAGRK
Ligand information
>8gzr Chain C (length=33) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguaguuugaacagguucugaaaagaaccuguu
.........<<<<<<<<<<....>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB8gzr Structures of dengue virus RNA replicase complexes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R226 T245 T246 A264 T265 R269 V274 P364 S365 I366 R388 T409 D410 I411 L430 P432 L444 R539 D542
Binding residue
(residue number reindexed from 1)		R50 T69 T70 A88 T89 R93 V98 P188 S189 I190 R212 T233 D234 I235 L254 P256 L268 R363 D366
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:8gzr, PDBe:8gzr, PDBj:8gzr
PDBsum8gzr
PubMed37478848
UniProtQ5I3C1

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