Structure of PDB 8gws Chain B Binding Site BS01

Receptor Information

>8gws Chain B (length=302) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDML
NPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSAGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI
TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SG

Ligand information

>8gws Chain D (length=8) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

VKLQAIFR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8gws SARS-CoV-2 Mpro 1-302 c145a in complex with peptide 4
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): T24 T25 T26 H41 L141 N142 G143 S144 A145 H163 H164 M165 E166 H172 Q189 Q192
• Binding residue (residue number reindexed from 1): T24 T25 T26 H41 L141 N142 G143 S144 A145 H163 H164 M165 E166 H172 Q189 Q192

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:8gws, PDBe:8gws, PDBj:8gws
• PDBsum: 8gws
• PubMed: 37609788
• UniProt: P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)