Structure of PDB 8ghf Chain B Binding Site BS01

Receptor Information
>8ghf Chain B (length=910) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCAAEVGWMTSVKDWAG
VMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQI
DMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRS
WLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGF
IHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRL
FMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHIT
LESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQ
GSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHP
KIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQG
LSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPT
VCELCFVKLKLLMIAIEYSRILINPGNHLKIQEGTLGFFIASDAKEVKRA
FFYCKVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDV
SSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNI
KSMQFDTTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA
FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYS
TPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGI
YRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDAAAAAAAA
AAAAAAAAAA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8ghf Chain B Residue 1502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ghf Membrane protein isolation and structure determination in cell-derived membrane vesicles.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D367 R514 S533 E535 S600
Binding residue
(residue number reindexed from 1)		D315 R462 S481 E483 S542
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ghf, PDBe:8ghf, PDBj:8ghf
PDBsum8ghf
PubMed37098056
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

[Back to BioLiP]