Structure of PDB 8gh7 Chain B Binding Site BS01
Receptor Information
>8gh7 Chain B (length=92) Species:
9606
(Homo sapiens) [
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TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHC
GGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT
Ligand information
>8gh7 Chain H (length=3) Species:
32630
(synthetic construct) [
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AGP
Receptor-Ligand Complex Structure
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PDB
8gh7
Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
Resolution
1.75 Å
Binding residue
(original residue number in PDB)
G306 L307 T308 D309 W310 K311 E314 Q319 W323 Y324
Binding residue
(residue number reindexed from 1)
G53 L54 T55 D56 W57 K58 E61 Q66 W70 Y71
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:8gh7
,
PDBe:8gh7
,
PDBj:8gh7
PDBsum
8gh7
PubMed
37262387
UniProt
P98170
|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)
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