Structure of PDB 8gck Chain B Binding Site BS01
Receptor Information
>8gck Chain B (length=128) Species:
9606
(Homo sapiens) [
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KSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYL
KMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAY
SLAKEQRLNFGDDIPSALRIAKKKRWNS
Ligand information
>8gck Chain E (length=6) Species:
9606
(Homo sapiens) [
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SIDMVD
Receptor-Ligand Complex Structure
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PDB
8gck
Intersecting PTMs regulate clearance of pathogenic tau by the ubiquitin ligase CHIP.
Resolution
1.36824 Å
Binding residue
(original residue number in PDB)
K31 N35 F38 Y50 N66 L69 K73 K96 F99 F132 D135
Binding residue
(residue number reindexed from 1)
K9 N13 F16 Y28 N44 L47 K51 K74 F77 F110 D113
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:8gck
,
PDBe:8gck
,
PDBj:8gck
PDBsum
8gck
PubMed
UniProt
Q9UNE7
|CHIP_HUMAN E3 ubiquitin-protein ligase CHIP (Gene Name=STUB1)
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