Structure of PDB 8g0h Chain B Binding Site BS01

Receptor Information
>8g0h Chain B (length=473) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKE
NRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN
FTKYPKKFYPLEIDYGGTKSKLPKPVQDLIKMIFDVESMKKAMYEIDLQK
MPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFG
MKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGDSSKDPIDVNYEKL
KTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQR
YKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYF
ADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHS
VKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQV
NLKYLLKLKFNFKTSLWLEHHHH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g0h Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
Resolution3.8 Å
Binding residue
(original residue number in PDB)		Y570 R587 W589 K600 K621 F638
Binding residue
(residue number reindexed from 1)		Y40 R57 W59 K70 K91 F108
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8g0h, PDBe:8g0h, PDBj:8g0h
PDBsum8g0h
PubMed38372302
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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