Structure of PDB 8g04 Chain B Binding Site BS01

Receptor Information
>8g04 Chain B (length=398) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPR
ACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVL
FVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRD
PKNSTGPTVIQLIATETCCPALQEGGSCLISGLQPGNSYWLQLRSEPDGI
SLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQG
FFYHSRARCCPRDRYPIWENCEEEQFSRCHFKSRNDSIIHILVEVTTAPG
TVHSYLGSPFWIHQAVRLPTPNLHWREIHLELEWQHPSSWAAQETCYQLR
YTGDWKVLEPPLGARGGTLELRYRLQLRARLNGPTYQGPWSSWSDPTR
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain8g04 Chain B Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g04 Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R257 W269
Binding residue
(residue number reindexed from 1)		R194 W206
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0038164 thrombopoietin receptor activity
Biological Process
GO:0001780 neutrophil homeostasis
GO:0007166 cell surface receptor signaling pathway
GO:0016064 immunoglobulin mediated immune response
GO:0035702 monocyte homeostasis
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0050671 positive regulation of lymphocyte proliferation
GO:0071456 cellular response to hypoxia
GO:1905221 positive regulation of platelet formation
GO:1990959 eosinophil homeostasis
GO:1990960 basophil homeostasis
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0043025 neuronal cell body

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g04, PDBe:8g04, PDBj:8g04
PDBsum8g04
PubMed37633268
UniProtP40238|TPOR_HUMAN Thrombopoietin receptor (Gene Name=MPL)

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