Structure of PDB 8ftm Chain B Binding Site BS01

Receptor Information

>8ftm Chain B (length=731) Species: 759272 (Thermochaetoides thermophila DSM 1495)

MRARLIPPMDVLHQAILEWDIFHEGCGNVSDTYPDPYSYKQTFFPLLINE
AWRSFVTAKDETTSKPFGIKVLSRMTVDKFMEVTAAVPAQISKDRGLTEG
DIVIISKGEDPLNQPQELHCLSRIWKTTYKKDTVEVVYRLNAKGNQILPA
LTPGSEFQVVKITNMTTIEREYAALESLQYYDLMDEILKAQPSPMLTFGD
EAIKAVMDNYQLNPGQARAILNAKENDGFTLIQGPPGTGKTKTIVAMVGC
LLTGVLPSKKLLVCAPSNAAVDELVLRLKAGVKTMNGTFHKIEVLRLGRS
DVINAAVKDVTLDELVKARMDAELSKNSSPSERDQLHKEAGEIKAKLAEI
RPQLDAARLSDDRASAMKLQREFDELKRRQAHIGAKIDADKASGNTYARE
TEIKRRQIQQEILDKAQVLCATLSGSGHEMFKNLNVEFETVIIDEAAQCV
ELSALIPLKYGCNKCILVGDPKQLPPTVLSQSAAKYGYDQSLFVRMQKNH
PKDVHLLDMQYRMHPEISRFPSKEFYEGLLQDGADMARLRLQPWHQSVLL
GPYRFFDVKGSQERGPKNQSLVNEEEVKVAMQLYMRFRSDYRDIDLTGKI
GIITPYKAQLQRLRQKFVERYGESITEQIEFNTTDAFQGRECEIIIFSCV
RASPTGGIGFMTDIRRMNVGLTRARSSLWILGDSRALVQGEFWAKLIEDA
KQRDRYTNGNIMALLSQPGPRVSLESLAKQY

Ligand information

>8ftm Chain D (length=10)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ftm Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.
• Resolution: 3.01 Å
• Binding residue (original residue number in PDB): T1273 R1276 P1394 S1395 N1396 G1426 R1427 D1441 T1550 H1556 M1558 T1605 L1607 Q1609 S1698 Y1734 K1735 T1761 D1763 G1787 F1788
• Binding residue (residue number reindexed from 1): T167 R170 P266 S267 N268 G298 R299 D313 T422 H428 M430 T477 L479 Q481 S570 Y606 K607 T633 D635 G659 F660

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Gene Ontology

Molecular Function

• GO:0004386 helicase activity

External links

• PDB: RCSB:8ftm, PDBe:8ftm, PDBj:8ftm
• PDBsum: 8ftm
• PubMed: 37832548
• UniProt: G0S163