Structure of PDB 8foe Chain B Binding Site BS01

Receptor Information
>8foe Chain B (length=370) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSEEEKKLYARLYESKLSFYDLPPQLEQFEIWAIDRLKILLEIESCLSR
NKSIKEIETIIKPQFQKLLPFNTESLEDRKKDYYSHFILRLCFCRSKELR
EKFVRAETFLFKIRFNMLTSTDQTKFVQSLQFISNEEKAELSHQLYQTVS
ASKFIKLPFENVIELVGNRLVFLKDGYAYLQQLNLLSNEFASKLNQELIK
TYQYLPRLNLPILNHLSSGYTDEINAQSVWSEEISSNYPLCIKNLMEGLK
KNHYYGRQQLSLFLKGIGLSADEALKFWSEAFTNPWDCHTILSKPRPGRG
DYHGCPFRDWSHERLSAELRSMKLTQAQIISVLDSCQKGEYTIACTKVFE
MTHHIAHPNLYFERSRQLQK
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8foe Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8foe Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Resolution5.6 Å
Binding residue
(original residue number in PDB)		P334 C336 C417 I420 C434 F436 T471 C474 P500
Binding residue
(residue number reindexed from 1)		P239 C241 C288 I291 C305 F307 T342 C345 P358
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003896 DNA primase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8foe, PDBe:8foe, PDBj:8foe
PDBsum8foe
PubMed37344454
UniProtP20457|PRI2_YEAST DNA primase large subunit (Gene Name=PRI2)

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