Structure of PDB 8foc Chain B Binding Site BS01

Receptor Information
>8foc Chain B (length=450) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSEEEKKLYARLYESKLSFYDLPPQGEITLEQFEIWAIDRLKILLEIES
CLSRNKSIKEIETIIKPQFQKLLPFNTESLEDRKKDYYSHFILRLCFCRS
KELREKFVRAETFLFKIRFNMLTSTDQTKFVQSLQFISNEEKAELSHQLY
QTVSASLQFQLNLNEEHQRKQYFQQEKFIKLPFENVIELVGNRLVFLKDG
YAYLQQLNLLSNEFASKLNQELIKTYQYLPRLNEDDRLLPILNHLSSGYT
DEINAQSVWSEEISSNYPLCIKNLMEGLKKNHHLRYYGRQQLSLFLKGIG
LSADEALKFWSEAFTRNGNMTMEKFNKEYRYSFRHNYGLEGNRINYKPWD
CHTILSKPRPGRGDYHGCPFRDWSHERLSAELRSMKLTQAQIISVLDSCQ
KGEYTIACTKVFEMTHNHIAHPNLYFERSRQLQKKQQKLEKEKLFNNGNH
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8foc Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8foc Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		P334 C336 C417 C434 P435 C474
Binding residue
(residue number reindexed from 1)		P268 C270 C351 C368 P369 C408
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003896 DNA primase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8foc, PDBe:8foc, PDBj:8foc
PDBsum8foc
PubMed37344454
UniProtP20457|PRI2_YEAST DNA primase large subunit (Gene Name=PRI2)

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