Structure of PDB 8fil Chain B Binding Site BS01
Receptor Information
>8fil Chain B (length=184) Species:
9606
(Homo sapiens) [
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RHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVQHRGFLHNQAKNL
LCGFYGRHAALRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRA
FLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCW
DTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQN
Ligand information
>8fil Chain E (length=13) [
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tgcgcttcgcgct
Receptor-Ligand Complex Structure
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PDB
8fil
DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
Resolution
2.01 Å
Binding residue
(original residue number in PDB)
R28 H29 T31 N57 A59 K60 H70 W98 S99 Y130 D131 Y132
Binding residue
(residue number reindexed from 1)
R19 H20 T22 N45 A47 K48 H58 W86 S87 Y118 D119 Y120
Enzymatic activity
Enzyme Commision number
3.5.4.38
: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003723
RNA binding
GO:0003824
catalytic activity
GO:0004126
cytidine deaminase activity
GO:0005515
protein binding
GO:0016787
hydrolase activity
GO:0046872
metal ion binding
Biological Process
GO:0010526
retrotransposon silencing
GO:0016554
cytidine to uridine editing
GO:0044029
positive regulation of gene expression via chromosomal CpG island demethylation
GO:0044355
clearance of foreign intracellular DNA
GO:0045071
negative regulation of viral genome replication
GO:0045087
innate immune response
GO:0045869
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0051607
defense response to virus
GO:0070383
DNA cytosine deamination
Cellular Component
GO:0000932
P-body
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:8fil
,
PDBe:8fil
,
PDBj:8fil
PDBsum
8fil
PubMed
37821454
UniProt
P31941
|ABC3A_HUMAN DNA dC->dU-editing enzyme APOBEC-3A (Gene Name=APOBEC3A)
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