Structure of PDB 8fhn Chain B Binding Site BS01

Receptor Information
>8fhn Chain B (length=847) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVG
VAMHTVGFAATVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGME
WESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLV
PDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIF
WTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTEC
TQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAP
IISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVI
MFLLTWWAALIAIGVVLFLLLYVIYSYNLALSYSVGLNEVEDHIKNYRPQ
CLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN
GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKK
NWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKEEQATTIFQS
EQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQ
ERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGF
KDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIV
ITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ
Ligand information
>8fhn Chain C (length=29) Species: 7955 (Danio rerio) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NTIDAVPKIDFYRQTKLIRPTLSELHDEL
Receptor-Ligand Complex Structure
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PDB8fhn Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H762 F765 D766 W835 L836 F837 D838 G840 R981 K982 R1009 Q1012 N1014 F1018 Y1019
Binding residue
(residue number reindexed from 1)		H618 F621 D622 W661 L662 F663 D664 G666 R807 K808 R835 Q838 N840 F844 Y845
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015377 chloride:monoatomic cation symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fhn, PDBe:8fhn, PDBj:8fhn
PDBsum8fhn
PubMed36792826
UniProtP55017|S12A3_HUMAN Solute carrier family 12 member 3 (Gene Name=SLC12A3)

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