Structure of PDB 8fhg Chain B Binding Site BS01

Receptor Information

>8fhg Chain B (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDSPFVIYDMN
SLMMGEDKIKFKHSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD
LNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ
DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE
TDMSLHPLLQEIYKDLY

Ligand information

>8fhg Chain D (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GLEDIIRKALM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fhg Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437
Resolution	1.8 Å
Binding residue (original residue number in PDB)	V293 T297 K301 L311 Q314 L318 K319 H323
Binding residue (residue number reindexed from 1)	V83 T87 K91 L101 Q104 L108 K109 H113

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:8fhg, PDBe:8fhg, PDBj:8fhg
PDBsum	8fhg
PubMed
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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