Structure of PDB 8ffz Chain B Binding Site BS01

Receptor Information
>8ffz Chain B (length=905) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVLTIYPDELVQIVSDKIASNKGKITLNQLWDISGKYFDLSDKKVKQFVL
SCVILKKDIEVYCDGAITTKNVTDIIGDANHSYSVGITEDSLWTLLTGYT
KKESTIGNSAFELLLEVAKSGEKGINTMDLAQVTGQDPRSVTGRIKKINH
LLTSSQLIYKGHVVKQLKLKKFINIRDHLATIVEVVKRSKNGIRQIIDLK
RELKFDKEKRLSKAFIAAIAWLDEKEYLKKVLVVSPKNPAIKIRCVKYVK
DIPDNFNATDLLQNQGLVMEEKEVLLNRFYPLQNQTYDIADKSGLKGIST
MDVVNRITGKEFQRAFTKSSEYYLESVGYRLFRIYDFEGKKKFFRLFTAQ
NFQKLTNPKGFDELGKSRTDLKTLNEDNFVALNNTVRFTTDSDGQDIFFW
HGERSLRSLQRQRAILKVMNTIGGVAYLREQFYESVSKYMGSTTTLDKKT
VRGDVDLMVESEKLGARTEPVSGRKIIFLPTVGEDAIQRYILKEKDSKKA
TFTDVIHDTEIYFKDGVQALIRAVVVTKSIKNEIMWDKITKLFPNNSLDN
LKKKWTARRVRMGHSGWRAYVDKWKKMLVLAIKSEKISLRDVEELDLIKL
LDIWTSFDEKEIKRPLFLYKNYEENRKKFTLVRDMSSMIQREISSLKKTY
TRKISASTKDLSKSQSDDYIRTVIRSILIESNEIEALKNVGNESIDNVIM
DMAKEKQIYLHGSKLECTDTLPDILENRGNYKDFGVAFQYRCKVNELLEA
GNAIVINQEPSDISSWVLIDLISGELLNMDVIPMVEIRTLTPPLIIYANS
QTKLNTARKSAVKVPLGKPFSRLWVNGSGSIRPNIWKQVVTMVVNEIIFH
PGITLSRLQSRCREVLSLHEISEICKWLLERQVLITTDFDGYWVNHNWYS
IYEST
Ligand information
>8ffz Chain I (length=151) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcatatcacctgcgtttccgttaaactatcggttgcggccatatctacca
gaaagcaccgtttcccgtccgatcaactgtagttaagctggtaagagcct
gaccgagtagtgtagtgggtgaccatacgcgaaactcaggtgctgcaatc
t
Receptor-Ligand Complex Structure
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PDB8ffz Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R144 K147 Y395 F404 R1063
Binding residue
(residue number reindexed from 1)		R144 K147 Y335 F344 R808
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0008301 DNA binding, bending
Biological Process
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0042791 5S class rRNA transcription by RNA polymerase III
GO:0071168 protein localization to chromatin
Cellular Component
GO:0000127 transcription factor TFIIIC complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ffz, PDBe:8ffz, PDBj:8ffz
PDBsum8ffz
PubMed37402369
UniProtP34111|TFC3_YEAST Transcription factor tau 138 kDa subunit (Gene Name=TFC3)

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