Structure of PDB 8f8z Chain B Binding Site BS01
Receptor Information
>8f8z Chain B (length=433) Species:
9606
(Homo sapiens) [
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NMATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYH
CPNCEKTHGKSTLKKVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLG
YMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTK
QKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLS
WVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEK
TFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIP
SGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNF
ETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALA
EHEDELPEHFKPSQLIKDLAKEIRLSENASKAV
Ligand information
>8f8z Chain F (length=8) Species:
9606
(Homo sapiens) [
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ARTKQTAR
Receptor-Ligand Complex Structure
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PDB
8f8z
A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
Resolution
3.3 Å
Binding residue
(original residue number in PDB)
Y14 T17 F19 M20 I21 E22 W29 E39 I45 D46 Y145 E150 V178 D179 Y182
Binding residue
(residue number reindexed from 1)
Y15 T18 F20 M21 I22 E23 W30 E40 I46 D47 Y129 E134 V162 D163 Y166
Enzymatic activity
Enzyme Commision number
1.14.11.-
External links
PDB
RCSB:8f8z
,
PDBe:8f8z
,
PDBj:8f8z
PDBsum
8f8z
PubMed
36596360
UniProt
O75151
|PHF2_HUMAN Lysine-specific demethylase PHF2 (Gene Name=PHF2)
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