Structure of PDB 8f5o Chain B Binding Site BS01

Receptor Information
>8f5o Chain B (length=1134) Species: 5689 (Leishmania tarentolae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFVYLSKRIAMPNGVKVTSIAWNDGQGWLACGGEKGLLKVLKVDGGPQGQ
RSGGLSSSQTLEGHDTTVDLVTWNQQYCKLTSSDVSGRIIVWVLHKGMWF
EEMVNNRNSSRVVDFAWNPSGTKICITYEDGAVIVGGVDGNRYWGRELPY
KLAKVCWGADGNSILFGTATGEVYVHDASSGEHLSQVEIKCNDGKAPSPL
AGLSWHPAWVERPEPLATLAVCYQSGKLQLMTSIGDETPCNVDRDLPAHF
ISWNPSGTVLAVTAATPATEENGPGIVTQFFSTEGVHLRTLRVSGKQCGG
ITWEGGGLRVAIGVDSSVYFANVRPNYKYCYFKKTAVFAFTVPDKVEESV
MFWNVNTNERRTKSVRGLQYMNACKDACVLISRPDTTQQQRMIQLVNAIG
SPLETRFIDMELYTYDMNSSAVVCCGDESIYIWQFRDPSTAVDALDPISM
QASRAESQERVIHVCDLVRGDTAPTMKVRSALTNDLISAMCVSETHMFVS
LESGTLHVYQLSPLQLVSKYILFARAQSMSVNCNSTQLAVIHLGGITNVY
CIEREKFSLVPCKADTIDGVELKDVWNLRWAVDDPHRFAVMEKTRMLVYN
HGVAEEPVQSCANLCKFKSLKIRTLQLDELLLDPERPRKDYIVDFEAQLL
RDMRAVLRDGTAKEAYEFAESHNTKKLWELLAEHTLFQLDFTYAEVAFIH
CKDYAAIQFVKRVRSLDDPKKQLAEVNAYYRRFDEAERLYKDVDRKDLAL
DLRYRLGDWFGVVRLVQEGALLFQAWENIGDHYASRQKWSKAAQYYTQCR
HYRKLARIFYIIEDYEMLTQLISMGEHDKELMVTLGNMLLTVGLAEEAAK
AFIAANEPRMAVNGCVQVNMWNRAIALAKEHRLEDVGQLLEKYAKYLIHR
ERLTEAIELYRKAGKHDEAATLLAQLGKRAALRDALKAKKFYVLSALEVQ
KYRTTAIRTLDAAWRGAEAYHFLLMCQQQMADRNFKAALVLAMRLIEYDD
LVAPVDGYSLIALTAYLVKNFGLCSKAFARLEQAERNDEAPRPFADLARH
IFMTHSPVDTSVDSVPCPTCGSFNKEWAQRCIKCQQPFNTCIVSGCAIVS
EDGAWQCSVCHRKALEAVVDKYRNCPLCHTPRKG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8f5o Chain B Residue 2000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f5o Mechanism of IFT-A polymerization into trains for ciliary transport.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		C1214 C1217 C1232
Binding residue
(residue number reindexed from 1)		C1107 C1110 C1125
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042073 intraciliary transport
Cellular Component
GO:0005930 axoneme
GO:0031514 motile cilium
GO:0036064 ciliary basal body

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8f5o, PDBe:8f5o, PDBj:8f5o
PDBsum8f5o
PubMed36563665
UniProtA0A640KAU8

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