Structure of PDB 8eyb Chain B Binding Site BS01

Receptor Information
>8eyb Chain B (length=294) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSP
FDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWE
QKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKS
YYTVRQLELENLTTQETREILHFHYTTWPAFGVPESPASFLNFLFKVRES
GSLSPEHGPVVVHASAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLL
EMRKFRMGLIATADQLRFSYLAVIEGAKFIMAAAQDQWKELSHE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8eyb Structure guided studies of the interaction between PTP1B and JAK.
Resolution2.349 Å
Binding residue
(original residue number in PDB)		N44 R45 Y46 R47 D48 F182 A215 S216 A217 G218 I219 G220 R221
Binding residue
(residue number reindexed from 1)		N43 R44 Y45 R46 D47 F181 A214 S215 A216 G217 I218 G219 R220
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8eyb, PDBe:8eyb, PDBj:8eyb
PDBsum8eyb
PubMed37316570
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

[Back to BioLiP]