Structure of PDB 8eti Chain B Binding Site BS01

Receptor Information
>8eti Chain B (length=332) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGSLGFLPRKRASRQRGKVKAFPKDDASKPVHLTAFLGYKAGMTHIVRDL
DRPGSKMHKREILEAVTVIETPPMVVVGVVGYVETPRGLRSLTTVWAEHL
SEEVKRRFYKNWFKSKKKAFTKYAKKYAESTQSINRELERIKKYCSVVRV
LAHTQIRKTPLAQKKAHLMEIQVNGGSVADKVEWAREHFEKTVDIKSTFE
QNEMIDVIGVTRGKGNAGYMHRTQLNSKIYRIGAGDDAKNASTDFDATEK
RITPMGGFVRYGVVENDFVMLNGATPGPVKRVLTLRKSLLTHTSRKALEP
VSLKWIDTASKFGHGRFQTPAEAKQFLGTLKK
Ligand information
>8eti Chain 1 (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucaaaucagguaggacuacgcgcugauaagcgcaggaaaagaaa
auaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuugaa
aucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcu
uugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagg
gugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucg
aagagucgaguugcagcucuaaauggguggucaucuaaagcuaaauauug
gcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacu
uugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauugg
aaaucagucuuaccugggugagaucaguagucucucgagacuaugcacuc
uaaccuggguaggucagcaucaguuuucgggggcggaaaaagaauaaggg
aagguggcuguuuauagcccuuguuguaauacguccacuggggacugagg
acugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgu
cuaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaa
aacccauccgcgaaggugggaacgcccuuguggcgugcaccaucgaaaga
gcauagcuguugggacccgaaagauggugaaccaucuaguagcugguucc
ugccgaaguuuccggauagcagaaacucagaucaguuuuaugaguaugua
aaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcg
ggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaag
aaaagguguuaguucaucuagacagcaggacgguggccauggaagucgga
auccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccuga
aaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuagc
uuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcagcgaaaccacagccuggggggccaggcaaaaucagcggcagucaag
cgcgacguugcuuuccuaucauaccgaagcagaauucgguaagcguggga
acugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaacc
guugauucagaucauugguauuugcggcgccgcggagcuaucaucugccg
gauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgaa
uguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcga
ugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaucg
aauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugc
ugagauuaagccuuuguucccaagauuug
........................<<<<<<....>>>>>.>.........
<<....>>..<<<<<......<<>>.....>>>>>..<<<..<.......
.<<.<<<<<<<.......>>>>>>>.>>........>....<<<<<.<<<
<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<
<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>.
.......<<<<<<>>>>>>.....<<<<<..>>>>>..>>>.........
.........................<<....>>...............<<
<<....>>>>..................................<<<<<<
<<<<<<.....<<<<<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>
>.>>>>>>>>..<<<<<<<<<<<<<<<<<<<<<<<........<<<<<<<
.................>>>>>>>.......>>>>>.>>>>>>>>>>...
.....<<<.....>>>....>>>>>>>>....>>>>>>>>>>>>..<<<<
.....>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<......
.>>>>...>>>...<<<<<..<<<<<.....>>>>>...>>>>>......
>>>>>>.>>>>>>..<<.<...<<<<<<..>>>>>>......>.>>..<<
<<<<......<<..>>..<<<<<<<<<<...<<<.<<<<<<<....>>>>
>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...
...<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>.
...>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..
........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<....
........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<....
.<<.>>....>>....<<<<<....>>>>>....<<<<<.<<<<<<...<
..>...>>>>>>.<<<...<.<<<<<<<......>>>>>>>...>.>>>.
.>>>>>......<<<<<<<..<<<<.<.<<<<<.................
>>>>>.><<<<<....<.<....<<<<..>>>>...>.>...>>>>>.<<
<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>.
...<<.......<<<<<<...>>.>>>>....>>........<<<<<...
.<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<
<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>
...>>>....>>>>.>>>>>...>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8eti Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Resolution3.7 Å
Binding residue
(original residue number in PDB)
G12 S13 L14 G15 F16 R19 R21 R24 Q25 R26 K28 K30 A31 M53 H55 R62 G64 S65 A75 Y92 E94 T95 P96 R97 L99 R100 S101 T104 W106 R116 F118 Y119 K120 N121 F123 K124 S125 K126 F130 K132 R150 Y154 R159 R167 A172 Q173 K174 K175 E180 T221 R222 G223 G225 N269 H274 R275 T276 Q277 N279 G309 R313 G315 G326 A327 T328 P329 K333 R334 L343 R348 K349 S363 K364 F365 G366 H367 L380 G381 L383 K384
Binding residue
(residue number reindexed from 1)
G2 S3 L4 G5 F6 R9 R11 R14 Q15 R16 K18 K20 A21 M43 H45 R52 G54 S55 A65 Y82 E84 T85 P86 R87 L89 R90 S91 T94 W96 R106 F108 Y109 K110 N111 F113 K114 S115 K116 F120 K122 R140 Y144 R149 R157 A162 Q163 K164 K165 E170 T211 R212 G213 G215 N216 H221 R222 T223 Q224 N226 G256 R260 G262 G273 A274 T275 P276 K280 R281 L290 R295 K296 S310 K311 F312 G313 H314 L327 G328 L330 K331
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8eti, PDBe:8eti, PDBj:8eti
PDBsum8eti
PubMed36423630
UniProtP40372|RL3A_SCHPO Large ribosomal subunit protein uL3A (Gene Name=rpl301)

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