Structure of PDB 8esr Chain B Binding Site BS01 |
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| >8esr Chain 1 (length=2143)
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uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaau
uugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaag
cugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucag
agagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgc
uuucgaagagucgaguugugcagcucuaaaugggugguucaucuaaagcu
aaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagauga
aaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaaggga
agcauuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaa
gggaagguggcuguuuauagcccuuguuguaauacguccacuggggacug
aggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccgu
cuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugau
gaaaacccauccgcgaaauggugaaugcaggugggaacgcccuggcgugc
accaucgaccguaagagcauagcuguugggacccgaaagauggugaacua
ugccugaauuggguauaggaaccaucuaguagcugguuccugccgaaguu
uccggauagcagaaacucagaucaguuuuauguguaaaaugagaguuucu
agugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacg
ugagguuaaggugccggaauguacgcucaucagagaaaagguguuaguuc
aucuagacagcaggacgguggccauggaagucggaauccgcuaaggagug
uguaacaacucaccugccgaaugaacuagcccugaaaauggauggcgcuu
aagcguacuacccauaccucaccgucuggguuagagaagcucagacgagu
aggcaggcguggagguuugugacgaagccuugggcgugagccugggucga
acagccucuagugcagaucuugguggaaguagcauucaaaugagaacuuu
gaagacugaaguggggaaagguuccaugugaacagcaguuggacaugggu
uagucgauccuaagagauagggaagcuccguaugaaaguugcacgauuuu
ucgugccuaucgaaagggaauccgguuaauauuccggaaccagaaggugg
aaucacggcaacguaaaugaaguuggagacgucggcgggagcccugggaa
gaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuauccgg
agcuaggguaugguguuuggaagaguucagcggcugaauccggugcgcuc
ucgacggcccuugaaaauccaacggaagguuuucacaucuggucguacuc
cuccaaggugccucuaguugauagaacaauguagauaagggaagucggca
aaaugggcccacugucccuaucuacuaucuagcgaaaccacagccugggg
aacgggccaggcaaaaucagcggcccuguugagcuugacucuaguuugca
gguggggaguuaaaguuaccacagggaucuuguggcagccaagcgcgacg
uugcuucggcucuuccuaucauaccgaagcagaauucgguaagcguugga
cccacuaauagggaacgugagcugggaccgucgugagacgguuagucuac
ugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaaccgu
ugauucagaucauugguauuugcggcugccugacaaggcaaugccgcgga
gcuaucaucugccggauaacggcugaacgccucuaagccagaauccgugc
cagaaagcgacgauauguauaaaaauagagguaggcuacucuccuguauc
guagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguc
caugaaauuccaugaauccauugcauacgacuuuaauguggaacggggua
uuguaagcagcugcugagauuaagccuuuguucccaagauuug |
........................<<<<<<........>>>>>.>.....
....<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<<.
......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<
<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((...
...<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>
>.>>........<<<<<<..>>>>>>.....<<<<<<.>>>>>>..>>>.
.................................<<....>>.........
......<<<<....>>>>................................
..<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<
<<<......<...>......>>>>>>>>......>>>>>.>>>>>>>>>>
........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<
........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<...
....>>>>...>>>...<<.>>.......<<<<<..<<<<<..>>>>>..
.>>>>>.<<.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...<<<
<<<<<<<.>>>>>>>>>>..>>>>>>......>.>>..<<<<<<......
<<..>>..<<<<<<<<<....<<<.<<<<<<..>>>>>>>>>.>>>>>>>
.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<
<<<<<<...<<<(((.....<<<<<<.....<<.....<<<.<<<<<<<<
<<.......<<<<<.<<....<<.........>>....>>.........<
<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>.
..>>>>>>.>>>...>>>>>>><<<<<<<<<.......>>>>>>>>>...
.>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...
>>>>>>>>>>........>>>>>><<.....<<.<<<<<<.......>>>
>>><<<<.....<<<...<<...<<<<<<.............>>>>>>..
..((<<<<<<...<<....<<<....>>>...........<<<<<.....
.>>>>>...>>....>>...<<<<<........>>>>>))<<<<..<<<<
<<..<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<
<<<...((..>>>>>>....<<<<<...<<<<<<....<<<.....>>>.
...>>>>>>.....>>>>>.....<<<<<<<.>>>>>>>>>>>...>>>>
>>>.>>>>.........>>>>>>......>>>.>>>.>>>>>>>>..>>.
.>>>.<<<..>>>..>>>>..<<<<.....<<<<<<<.<<.........<
....<<..>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<..
......>>>>>....<<<<<.<.<<<<<.<<<<<<<<<<<<<.<<<<..>
>>>..>>>>>>.>>>>>..>>>>>>>.......<<<<<<...<..>...>
>>>>>.<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.
.>>>.....>>>>.......>>>>.<<<<<<<....>>>>>>>....>.>
>>>>.....<<<<<<<<..<<<<.<.<<<<<.................>>
>>>.><<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...
>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>
>>....>>>>>>>>....<<.......<<<<..<..>..>>>>....>>.
.......<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>
>>>..........<<<<<.<.............>.....<<<<<<<<<.<
<<....<<<..>>>...>>>....>>>>.>>>>>...>>>>>. |
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| PDB | 8esr Chromatin localization of nucleophosmin organizes ribosome biogenesis. |
| Resolution | 3.2 Å |
Binding residue
(original residue number in PDB) | S13 L14 G15 F16 P18 R19 K20 R21 Q25 R26 K28 K30 A31 M53 H55 R62 P63 G64 S65 A75 Y92 T95 P96 R97 L99 R100 S101 L102 T103 T104 R116 R117 Y119 K120 N121 F123 K124 K126 K128 F130 K132 Y133 R150 Y154 R159 R167 Q173 K174 K175 E180 T221 R222 G223 K224 N226 H274 R275 T276 L278 N279 M308 G309 R313 G315 G326 A327 T328 K333 R334 R339 L343 R348 S363 K364 F365 G366 H367 L380 G381 K384 K385 |
Binding residue
(residue number reindexed from 1) | S3 L4 G5 F6 P8 R9 K10 R11 Q15 R16 K18 K20 A21 M43 H45 R52 P53 G54 S55 A65 Y82 T85 P86 R87 L89 R90 S91 L92 T93 T94 R106 R107 Y109 K110 N111 F113 K114 K116 K118 F120 K122 Y123 R140 Y144 R149 R157 Q163 K164 K165 E170 T211 R212 G213 K214 N216 H224 R225 T226 L228 N229 M258 G259 R263 G265 G276 A277 T278 K283 R284 R289 L293 R298 S313 K314 F315 G316 H317 L330 G331 K334 K335 |
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