Structure of PDB 8erp Chain B Binding Site BS01

Receptor Information
>8erp Chain B (length=364) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLSAQQLKKLEEHKYSASGRSLVEPPMQVYWNWLVEKVPLWLAPNTITMV
GLLLNVLSTLILVCYCPTATEGAPFWTYLLCAIGLFVYQSLDAIDGKQAR
RTNSSSPLGEMFDHGCDSISIVFVNLGTIAAVRLGTLPGWMFYCCFVGMF
MFYCAQWQTYVCGTLKFGIIDVTELQISVTVMFLMTAVCGPELWDYEIPF
TGLPMKTIPLLGIIGGTVYSCSNYFRVILSGGVGKNGSTVAGTSVLSPGL
HIGLVLLLALMIYKKSTTNLFLQNPCLYTLAFGFVSAKITIKLVIAHMTK
SEISLQDTAFIGPGLLFFNQYFNSFIDEYIVLWIAMVISFADLLRYCISV
CLQIATHLRISVFR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8erp Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8erp Substrate recognition and catalysis in eukaryotic cholinephosphotransferase-1
Resolution3.7 Å
Binding residue
(original residue number in PDB)		D111 D132 D136
Binding residue
(residue number reindexed from 1)		D92 D113 D117
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.8.2: diacylglycerol cholinephosphotransferase.
Gene Ontology
Molecular Function
GO:0004142 diacylglycerol cholinephosphotransferase activity
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0046872 metal ion binding
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8erp, PDBe:8erp, PDBj:8erp
PDBsum8erp
PubMed37179328
UniProtQ4KLV1|CHPT1_XENLA Cholinephosphotransferase 1 (Gene Name=chpt1)

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