Structure of PDB 8ehn Chain B Binding Site BS01

Receptor Information
>8ehn Chain B (length=155) Species: 28344 (Porcine reproductive and respiratory syndrome virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGITTYSPPTDGSCGWHVLAAIVNRMINGDFTSPLPQYNRPEDDWASDYD
LAQAIQCLQLPATVVRNRACPNAKYLIKLNGVHWEVEVRSGMAPRSLSRE
CVVGVCSEGCVAPPYPADGLPKRALEALASAYRLPSDCVSSGIADFLADP
PPQEF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ehn Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ehn Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C485 C516 C521 C525
Binding residue
(residue number reindexed from 1)		C70 C101 C106 C110
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.22.-
Gene Ontology
Biological Process
GO:0016032 viral process
GO:0019082 viral protein processing

View graph for
Biological Process
External links
PDB RCSB:8ehn, PDBe:8ehn, PDBj:8ehn
PDBsum8ehn
PubMed38096325
UniProtP0DJY0|1ATF_PRRSS Truncated polyprotein 1aTF

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