Structure of PDB 8egw Chain B Binding Site BS01

Receptor Information
>8egw Chain B (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYTT
STIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVT
FKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNP
SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDI
NDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEG
TPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQL
LDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGN
ISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDN
YGAPPGAAVQARSSVASLVIFVND
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8egw Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8egw Structure of the planar cell polarity cadherins Fat4 and Dachsous1.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		N129 N131 D161 D163 N167 D224
Binding residue
(residue number reindexed from 1)		N86 N88 D118 D120 N124 D181
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8egw, PDBe:8egw, PDBj:8egw
PDBsum8egw
PubMed36797229
UniProtQ6V0I7|FAT4_HUMAN Protocadherin Fat 4 (Gene Name=FAT4)

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