Structure of PDB 8e3i Chain B Binding Site BS01

Receptor Information
>8e3i Chain B (length=376) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYND
LVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSG
EFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSN
MNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILR
GHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTV
MEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHP
VHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILC
SGSNDHTSKFWTRNRPGDKMRDRYNL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e3i Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		F43 D44 G45 R47 M48 R49 R54 K117 F153 I156
Binding residue
(residue number reindexed from 1)		F2 D3 G4 R6 M7 R8 R13 K76 F112 I115
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0031124 mRNA 3'-end processing

View graph for
Biological Process
External links
PDB RCSB:8e3i, PDBe:8e3i, PDBj:8e3i
PDBsum8e3i
PubMed36130077
UniProtQ9C0J8|WDR33_HUMAN pre-mRNA 3' end processing protein WDR33 (Gene Name=WDR33)

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