Structure of PDB 8e2s Chain B Binding Site BS01

Receptor Information

>8e2s Chain B (length=151) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MSEVEFSHEYWMRHALTLAKRARDERGVPVGAVLVLNNRVIGEGWNRANG
LHDPTAHAEIMALRQGGLVMQNYRLYDATLYSTFEPCVMCAGAMIHSRIG
RVVFGVRNAKTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLCRFFR
M

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8e2s Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8e2s Improved cytosine base editors generated from TadA variants.
Resolution	2.95 Å
Binding residue (original residue number in PDB)	H57 C87 C90
Binding residue (residue number reindexed from 1)	H57 C87 C90
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.4.33: tRNA(adenine(34)) deaminase.

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0008251	tRNA-specific adenosine deaminase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0052717	tRNA-specific adenosine-34 deaminase activity

	Biological Process
GO:0002100	tRNA wobble adenosine to inosine editing
GO:0006382	adenosine to inosine editing
GO:0008033	tRNA processing

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Molecular Function

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Biological Process

External links

PDB	RCSB:8e2s, PDBe:8e2s, PDBj:8e2s
PDBsum	8e2s
PubMed	36624149
UniProt	P68398\|TADA_ECOLI tRNA-specific adenosine deaminase (Gene Name=tadA)

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