Structure of PDB 8dwk Chain B Binding Site BS01

Receptor Information
>8dwk Chain B (length=294) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
Ligand information
>8dwk Chain D (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KKVEWTSDTVDNEHMGRRSSKCCC
Receptor-Ligand Complex Structure
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PDB8dwk Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y134 I169 N219 R221 D242 L243 V250 E252 D253 Y255 F257 A259 K260 R261 C273 F276 L289 M290 C291 F293
Binding residue
(residue number reindexed from 1)		Y129 I164 N214 R216 D237 L238 V245 E247 D248 Y250 F252 A254 K255 R256 C268 F271 L284 M285 C286 F288
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8dwk, PDBe:8dwk, PDBj:8dwk
PDBsum8dwk
PubMed37002212
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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