Structure of PDB 8dh1 Chain B Binding Site BS01

Receptor Information
>8dh1 Chain B (length=855) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARF
RKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPT
AFQFLQEIKPEAVAYITIKTTLACLTSNTTVQAVASAIGRAIEDEARFGR
IRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSS
WHKEDSIHVGVRCIEMLIESTGMVSLHRQNAGVVGQDSETIELAPEYAEA
IATRAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKK
ALMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIP
AIEALTAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYN
MDWRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAG
VDKVPFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYA
GVQHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQD
IYGIVAKKVNEILQADAINGTDNEVVTVTDENTGEISEKVKLGTKALAGQ
WLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQ
PNQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEIL
RKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQFRDSEIDAHKQESGI
APNFVHSQDGSHLRKTVVWAHEKYGIESFALIHDSFGTIPADAANLFKAV
RETMVDTYESCDVLADFYDQFADQLHESQLDKMPALPAKGNLNLRDILES
DFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh1 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		R50 R57 E63 R298 H300 W422 R423 Y427 R632 Y639 S641 F644 Q648 Q649 Y739 H772 P780 H784
Binding residue
(residue number reindexed from 1)		R49 R56 E62 R295 H297 W403 R404 Y408 R613 Y620 S622 F625 Q629 Q630 Y720 H744 P752 H756
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh1, PDBe:8dh1, PDBj:8dh1
PDBsum8dh1
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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