Structure of PDB 8dh0 Chain B Binding Site BS01

Receptor Information
>8dh0 Chain B (length=840) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEAR
FRKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRP
TAFQFLQEIKPEAVAYITIKTTLACLTSNTTVQAVASAIGRAIEDEARFG
RIRDAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSW
HKEDSIHVGVRCIEMLIESTGMVSLHRQNAGVVGQDSETIELAPEYAEAI
ATRAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKA
LMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPA
ITAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWR
GRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKV
PFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQH
HGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGI
VAKKVNEILQADAINGTDNEVVTVTEKVKLGTKALAGQWLAYGVTRSVTK
RSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLI
WESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPD
GFPVWQEYKKPIQTRLNLMFLGQSEIDAHKQESGIAPNFVHSQDGSHLRK
TVVWAHEKYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLA
DFYDQFADQLHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh0 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R50 R57 E63 R298 I396 W422 R423 Y427 R632 Y639 S641 F644 Q648 Q649 Y739 H772 P780
Binding residue
(residue number reindexed from 1)		R50 R57 E63 R294 I373 W399 R400 Y404 R601 Y608 S610 F613 Q617 Q618 Y708 H729 P737
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh0, PDBe:8dh0, PDBj:8dh0
PDBsum8dh0
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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