Structure of PDB 8d8n Chain B Binding Site BS01

Receptor Information
>8d8n Chain B (length=1256) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAGK
SFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSFL
RKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFSN
FDLDHKQEKNDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGTY
TGRITLRNEHAKKLLLASLGFVDKLCGALCRIEVIKKEVLSEDHNDELRK
QAEVIVEAFKQNDKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDK
GHHLWDIKVQGTALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETG
IETKEWIIVGRLKAATPFYFGVQQPSDSIPGVINEHTSFNILLDKENRYR
IPRSALRGALRRDLRTAFGSGCNVSLGGQILCNCKVCIEMRRITLKDSVS
DFSEPPEIRYRIAKNPGTATVEDGSLFDIEVGPEGLTFPFVLRYRGHKFP
EQLSSVIRYWEENDGKNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQKIN
EYIKERGMRGKEKELLEMGESSLPDGLIPYKFFEERECLFPYKENLKPQW
SEVQYTIEVGSPLLTADTISALTEPGNRDAIAYKKRVYNDGNNAIEPEPR
FAVKSETHRGIFRTAVGRRTGDLGKEDHEDCTCDMCIIFGNEHESSKIRF
EDLELINGNEFEKLEKHIDHVAIDRFTGGALDKAKFDTYPLAGSPKKPLK
LKGRFWIKKGFSGDHKLLITTALSDIRDGLYPLGSKGGVGYGWVAGISID
DNVPDDFKEMINKTEGPINNDYVHPGHQSPKQDHKNKNIYYPHYFLDSGS
KVYREKDIITHEEFTEELLSGKINCKLETLTPLIIPDTSDENGLKLQGNK
PGHKNYKFFNINGELMIPGSELRGMLRTHFEALTKSCFAIFGEDSTLSWR
RKCASKTLGGKLDKALHPCTGLSDGLCPGCHLFGTTDYKGRVKFGFAKYE
NGPEWLITRGNNPERSLTLGVLESPRPAFSIPDDESEIPGRKFYLHHNGW
RIIRQKQLEIRETVQPERNVTTEVMDKGNVFSFDVKFENLREWELGLLLQ
SLDPGKNIAHKLGKGKPYGFGSVKIKIDSLHTFKINSNNDKIKRVPQSDI
REYINKGYQKLIEWSGNNSIQKGNVLPQWHVIPHIDKLYKLLWVPFLNDS
KLEPDVRYPVLNEESKGYIEGSDYTYKKLGDKDNLPYKTRVKGLTTPWSP
WNPFQV
Ligand information
>8d8n Chain C (length=35) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acuuaaugucacgguacccaauuuucugccccgga
...................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d8n Craspase is a CRISPR RNA-guided, RNA-activated protease.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		W21 R32 Q34 T40 F52 T56 L57 R59 S60 F87 Q88 T89 D90 S98 F99 L100 R101 K102 K136 E139 F148 N150 I172 N174 V176 D185 F187 K224 G426 R467 S468 A469 R471 S489 L490 G491 L495 R505 R525 I526 K528 V535 F541 G588 L589 S591 A680 R723 G724 R727 T728 G754 H784 V785 I787 R789 K799 F800 S849 K850 P967 T969 S1001 E1002 R1004 R1008 T1422 E1460 S1461 R1463 F1466 Y1481 K1551 G1552 K1553 P1554 Y1645 L1648 Y1663
Binding residue
(residue number reindexed from 1)		W21 R32 Q34 T40 F52 T56 L57 R59 S60 F87 Q88 T89 D90 S98 F99 L100 R101 K102 K136 E139 F148 N150 I172 N174 V176 D185 F187 K224 G371 R403 S404 A405 R407 S425 L426 G427 L431 R441 R461 I462 K464 V471 F477 G524 L525 S527 A616 R659 G660 R663 T664 G690 H720 V721 I723 R725 K735 F736 S785 K786 P886 T888 S920 E921 R923 R927 T985 E1023 S1024 R1026 F1029 Y1044 K1114 G1115 K1116 P1117 Y1208 L1211 Y1226
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8d8n, PDBe:8d8n, PDBj:8d8n
PDBsum8d8n
PubMed36007061
UniProtA0A0B0EGF3

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