Structure of PDB 8d80 Chain B Binding Site BS01

Receptor Information
>8d80 Chain B (length=381) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPG
QTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAY
REEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTM
SAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWL
YSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVL
RIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCG
PMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKIC
ASHIGWKFTATKKDMSPQKFWGLTRSALLPT
Ligand information
>8d80 Chain C (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GERPFQCNQCGASFTQKGNLLRHIKLHSG
Receptor-Ligand Complex Structure
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PDB8d80 Molecular glue CELMoD compounds are regulators of cereblon conformation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		Y355 H397
Binding residue
(residue number reindexed from 1)		Y311 H353
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0034766 negative regulation of monoatomic ion transmembrane transport
GO:0035641 locomotory exploration behavior
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902607 negative regulation of large conductance calcium-activated potassium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d80, PDBe:8d80, PDBj:8d80
PDBsum8d80
PubMed36378961
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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