Structure of PDB 8d7p Chain B Binding Site BS01

Receptor Information
>8d7p Chain B (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW
Ligand information
>8d7p Chain D (length=11) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ERDSVMLGEIA
Receptor-Ligand Complex Structure
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PDB8d7p PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		S17 S19 D128 N172 L173 T174 G175 T176 A177 R178 H185 G187 Q214 G215 K221 K224 Y225
Binding residue
(residue number reindexed from 1)		S16 S18 D127 N171 L172 T173 G174 T175 A176 R177 H184 G186 Q213 G214 K220 K223 Y224
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d7p, PDBe:8d7p, PDBj:8d7p
PDBsum8d7p
PubMed37207626
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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