Structure of PDB 8d7n Chain B Binding Site BS01

Receptor Information
>8d7n Chain B (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d7n PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.
Resolution1.66 Å
Binding residue
(original residue number in PDB)		G18 S19 R127 D128 K130 D149 L152 K171 L173 T174 G175 T176 R178 Q214 K224 Y225
Binding residue
(residue number reindexed from 1)		G17 S18 R126 D127 K129 D148 L151 K170 L172 T173 G174 T175 R177 Q213 K223 Y224
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d7n, PDBe:8d7n, PDBj:8d7n
PDBsum8d7n
PubMed37207626
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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