Structure of PDB 8d40 Chain B Binding Site BS01

Receptor Information
>8d40 Chain B (length=427) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGL
FDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATT
YITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINAN
LRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPG
PLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRD
QGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ
DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHI
QAVDADSGENARLHYRLVDTAPDFPFQIHNSSGWITVCAELDREEVEHYS
FGVEAVDHGSPPMSSSTSVSITVLDVN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8d40 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8d40 Crystal structure of human CELSR1 EC1-4
Resolution3.554 Å
Binding residue
(original residue number in PDB)		E21 E79 D110 T111 D113 D146
Binding residue
(residue number reindexed from 1)		E19 E77 D108 T109 D111 D144
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d40, PDBe:8d40, PDBj:8d40
PDBsum8d40
PubMed
UniProtQ9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)

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