Structure of PDB 8d0k Chain B Binding Site BS01

Receptor Information

>8d0k Chain B (length=362) Species: 9606 (Homo sapiens)

RCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQ
VDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARE
LSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATTYYKVD
DPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTS
LLSEKAKEFLMENRVQSFYQQELEMVESLLSLANQPVIHSASSDQVNFKK
DTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKIHR
IIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSD
IVSTMEHYYTAF

Ligand information

>8d0k Chain H (length=20)

tagggttagggttagggtta

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d0k Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
• Resolution: 4.27 Å
• Binding residue (original residue number in PDB): L24 R67 R69 W89 R139 Y141 R142
• Binding residue (residue number reindexed from 1): L18 R61 R63 W83 R133 Y135 R136

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003697 single-stranded DNA binding
• GO:0005515 protein binding
• GO:0042162 telomeric DNA binding
• GO:0043047 single-stranded telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0010833 telomere maintenance via telomere lengthening
• GO:0016233 telomere capping
• GO:0032211 negative regulation of telomere maintenance via telomerase
• GO:0045740 positive regulation of DNA replication

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0001650 fibrillar center
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0043231 intracellular membrane-bounded organelle
• GO:0045111 intermediate filament cytoskeleton
• GO:1990879 CST complex

External links

• PDB: RCSB:8d0k, PDBe:8d0k, PDBj:8d0k
• PDBsum: 8d0k
• PubMed: 35830881
• UniProt: Q9H668|STN1_HUMAN CST complex subunit STN1 (Gene Name=STN1)