Structure of PDB 8cxw Chain B Binding Site BS01

Receptor Information
>8cxw Chain B (length=549) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYD
LFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLT
NKKVVNDLDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKY
KKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSG
KDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVF
KIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYN
KIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIK
SKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECK
SGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSF
FIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKI
RIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cxw Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		Y30 N165 Y168 H171 K173 K193 Y221 S227 F253 I256 G257 F345 Q346 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		Y2 N137 Y140 H143 K145 K165 Y193 S199 F225 I228 G229 F317 Q318 R404 W411 R413 K428 Y448 K483 M485 S486 Y493 P494 N495
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxw, PDBe:8cxw, PDBj:8cxw
PDBsum8cxw
PubMed36581322
UniProtQ183J3

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