Structure of PDB 8cro Chain B Binding Site BS01

Receptor Information
>8cro Chain B (length=1098) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVTPDDLWIVMESYWQEKGLVRQHLDSYNAFIERGLQEVVNEFGGIKPDI
PDFEVKFGKIRVGEPEFQEPHGQRKPLYPMDARIRNLTYAAPLYLEMIPV
IKGVEQDPVEVRIGELPIMLKSKVCRLYGLSDEELIKLGEDPKDPGGYFI
INGSERVIVSIEDIAPNRTLVEKDERQEKYIAKVFSYRHGYRALVAVERR
KDGILYVDIPNVPKPVKFVYVMRALGLERDKDIVEAVGNDPEVQQIMFDN
LEDASDITTQQEALEFIGKLVAPGQAREYRLKRAEYVIDNNLLPHMGVSP
EDRIKKAYYLGMMALKVIELSLGRRPEDDKDHYANKRLRLAGDLLKDLFR
VAFSQLVKDIQYQMTKTYQRKGDKYTFGNIHRFIRNSIRPDVLTERIEHA
LATGAWPGGRTGVSQLLDRTNYMSTLSHLRRVTSPLDREQPHFEARDLHG
THWGRICPTETPEGPNCGLVKNLALMAQITTAVPEEEIREYLMSLGIVPI
EVRRPDPTLWRVYLNGVLIGTIEDGKALVQRIRQDRRSGKISDVINVAYY
EDVKEVYVNSDDGRVRRPLIIVENGVPKLTKEHVQAVKEGRLKWSDLIKM
GIIEYLDAEEEENAYVAMWPWEVTEEHTHLELMPAAILGLPASLVPYPEH
NAAPRNTYGAGMAKQSLGLGWANFRIRVDTRGHLLHYPQIPLVNSRIMKA
VGYEDRPAGQNFVVAVLAYQGYNMEDAIIINKASIERGLARSTFFRTYEA
EEKKYLGGQTDKFEIPDPTVRGYRGEKYYRNLDEDGLIFPESKVEGKDVL
VGRTSPPRFLERRETSVAVRPSEKGVVDKVIITETGDGTKLVKVTVRDLR
IPELGDKFASRHGQKGVIGLIVPQEDMPWTESGIVPDLIVNPHGIPSRMT
VGQLIEAIGGKVASLKGRRVDGTAFIGEPEEKLRKELEELGFKHTGREIM
YDGITGKRLEADIFIGVIYYQRLHHMVADKIHARSRGPVQVLTKQPTEGR
AREGGLRFGEMERDVLVGHGAAMLLIERLLEESDKTEVWVCENCGHIALE
DKRRRRVYCPVCGEEERISKVEMSYAFKLLLDELKAMVIRPKLNLSER
Ligand information
Receptor-Ligand Complex Structure
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PDB8cro Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T687 R688 R753 R838 R1018 R1025
Binding residue
(residue number reindexed from 1)		T680 R681 R746 R820 R1000 R1007
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cro, PDBe:8cro, PDBj:8cro
PDBsum8cro
PubMed38709902
UniProtQ8U0M3

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