Structure of PDB 8coy Chain B Binding Site BS01

Receptor Information
>8coy Chain B (length=337) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GYKFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPD
LRNNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVSNSGDPMDDNYHGTH
VSGIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCIS
RQAHMISGSFSFDEYSNIFSASVEHLRSLGILFFVSASNCAHDDIAKCDL
AVNHRYPPILSKTHNNVIAVANLKRDLDESYSLSVNSFYSNIYCQLAAPG
TNIYSTTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRN
AIVKLPSLTERVSWGGYVDILRAVNLAIDSKAAPYIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8coy 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.
Resolution1.507 Å
Binding residue
(original residue number in PDB)		Y371 H372 L405 K409 G411 S434 F435 S436 N464 N546 G547 T548 S549
Binding residue
(residue number reindexed from 1)		Y96 H97 L130 K134 G136 S159 F160 S161 N189 N266 G267 T268 S269
Enzymatic activity
Enzyme Commision number 3.4.21.62: subtilisin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8coy, PDBe:8coy, PDBj:8coy
PDBsum8coy
PubMed37428845
UniProtE6Y8B9

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