Structure of PDB 8cls Chain B Binding Site BS01

Receptor Information
>8cls Chain B (length=853) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTE
VTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGL
HKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKEC
RLSKCPGEIRSCQLHNNRRLCWNSKLCQTKCPEKCRNNCIDEHTCCSQDC
LGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDSRCVTANECITL
TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSG
LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQ
SSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGP
NQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGN
RGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAF
IGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYS
YYVRTMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWS
YLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVEYDDRKVQAGMEFE
NALQNFIFVPKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLR
HFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIV
MDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK
CIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPS
YAK
Ligand information
>8cls Chain C (length=24) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DFRGVVDSCCRNSCSFSTLRAYCD
Receptor-Ligand Complex Structure
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PDB8cls Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		R659 E660 H662
Binding residue
(residue number reindexed from 1)		R309 E310 H312
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:8cls, PDBe:8cls, PDBj:8cls
PDBsum8cls
PubMed37805602
UniProtP09208|INSR_DROME Insulin-like receptor (Gene Name=InR)

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