Structure of PDB 8clj Chain B Binding Site BS01

Receptor Information
>8clj Chain B (length=689) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVTRREPAVKLQYAVSGLEPLAWSEDHRVSVSTARSIAVLELICDVHNPG
QDLVIHRTSVPAPLNSCLLKVGSKTEVAECKEKFAASKDPTVSQTFMLDR
VFNPEGKALPPMRGFKYTSWSPMGCDANGRCLLAALTMDNRLTIQANLNR
LQWVQLVDLTEIYGERLYETSYRLSKNEAPEGNLGDFAEFQRRHSMQTPV
RMEWSGICTVGSVLLAVLFENGNIAVWQFQLPFVGKESISSCNTIESGIT
SPSVLFWWEYEHNNRKMSGLIVGSAFGPIKILPVNLKAVKGYFTLRQPVI
LWKEMDQLPVHSIKCVPLYHPYQKCSCSLVVAARGSYVFWCLLLISKAGL
NVHNSHVTGLHSLPIVSMTADKQNGTVYTCSSDGKVRQLIPIFTDVALKF
EHQLIKLSDVFGSVRTHGIAVSPCGAYLAIITTEGMINGLHPVNKNYQVQ
FVTLKTFEEAAAQLLESSVQNLFKQVDLIDLVRWKILKDKHIPQFLQEAL
EKKIESSGVTYFWRFKLFLLRILYQSMQKEPMEEKLLEIQGKIEAVEMHL
TREHMKRVLGEVYLHTWITENTSIPTRGLCNFLMSDEEYDDRTARVLIGH
ISKKMNKQTFPEHCSLCKEILPFTDRKQAVCSNGHIWLRCFLTYQSCQSL
IYRRCLLHDSIARHPAPEDPDWIKRLLQSPCPFCDSPVF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8clj Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8clj Structural insights into human TFIIIC promoter recognition.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C788 D792 S793 C814
Binding residue
(residue number reindexed from 1)		C655 D659 S660 C681
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0016746 acyltransferase activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0042791 5S class rRNA transcription by RNA polymerase III
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000127 transcription factor TFIIIC complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8clj, PDBe:8clj, PDBj:8clj
PDBsum8clj
PubMed37418517
UniProtQ9UKN8|TF3C4_HUMAN General transcription factor 3C polypeptide 4 (Gene Name=GTF3C4)

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