Structure of PDB 8cgp Chain B Binding Site BS01

Receptor Information
>8cgp Chain B (length=859) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNII
LHSTGHNISRVTFMSSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLK
IEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPA
FKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEI
QYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTK
IIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYED
FLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLK
TYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTW
TLQKGFPLVTVQKKGKELFIQQERFFLNMKTSYLWHIPLSYVTEGRNYSK
YQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLK
INPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITE
ALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMR
ELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVG
AKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGD
NFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIV
AGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKN
LKSLTWWLR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8cgp Chain B Residue 1106 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cgp Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		H464 H468 E487
Binding residue
(residue number reindexed from 1)		H304 H308 E327
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8cgp, PDBe:8cgp, PDBj:8cgp
PDBsum8cgp
PubMed38244767
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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