Structure of PDB 8c8q Chain B Binding Site BS01

Receptor Information
>8c8q Chain B (length=238) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAPSSWALYFQDGASPSYLGVTHLNDYLMFYLTFIFIGVIYAICKAVIEY
NYNSHPIAAKYTTHGSIVEFIWTLIPALILILVALPSFKLLYLLDEVQKP
SMTVKAIGRQWFWTYELNDFVTNENEPVSFDSYMVPEEDLEEGSLRQLEV
DNRLVLPIDTRIRLILTSGDVIHSWAVPSLGIKCDCIPGRLNQVSLSIDR
EGLFYGQCSELCGVLHSSMPIVVQGVSLEDFLAWLEEN
Ligand information
Ligand IDCUA
InChIInChI=1S/2Cu
InChIKeyALKZAGKDWUSJED-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cu][Cu]
FormulaCu2
NameDINUCLEAR COPPER ION
ChEMBL
DrugBank
ZINC
PDB chain8c8q Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8c8q Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor.
Resolution3.36 Å
Binding residue
(original residue number in PDB)		H182 E219 C221 H225 M228
Binding residue
(residue number reindexed from 1)		H173 E210 C212 H216 M219
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.
Gene Ontology
Molecular Function
GO:0004129 cytochrome-c oxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
GO:0022900 electron transport chain
GO:0042773 ATP synthesis coupled electron transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0045277 respiratory chain complex IV

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8c8q, PDBe:8c8q, PDBj:8c8q
PDBsum8c8q
PubMed36797353
UniProtP21534|COX2_SCHPO Cytochrome c oxidase subunit 2 (Gene Name=cox2)

[Back to BioLiP]