Structure of PDB 8bcb Chain B Binding Site BS01

Receptor Information
>8bcb Chain B (length=1721) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALK
PKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLL
CAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEM
VGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGG
ERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGL
SATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRF
QIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLF
LREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLF
ADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQ
MLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDML
NAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQ
RRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTY
NQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKES
IEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLN
RGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFE
RLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVE
LTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHL
ITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTEL
LDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAP
TGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRL
NKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLF
VVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVA
HWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAIT
KHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYL
EKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLC
WGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGR
CVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDA
VDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKC
ISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISN
AAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSR
MQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQ
AMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTD
SQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPV
IAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGA
HNYTLYFMSDAYMGCDQEYKF
Ligand information
Ligand IDSAN
InChIInChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
InChIKeyFDDDEECHVMSUSB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc(ccc1N)S(=O)(=O)N
CACTVS 3.341Nc1ccc(cc1)[S](N)(=O)=O
ACDLabs 10.04O=S(=O)(c1ccc(N)cc1)N
FormulaC6 H8 N2 O2 S
NameSULFANILAMIDE
ChEMBLCHEMBL21
DrugBankDB00259
ZINCZINC000000002101
PDB chain8bcb Chain B Residue 2216 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8bcb Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2.
Resolution2.38 Å
Binding residue
(original residue number in PDB)		N1101 N1531 I1532 S1533 Q1707 G1708
Binding residue
(residue number reindexed from 1)		N700 N1130 I1131 S1132 Q1306 G1307
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:8bcb, PDBe:8bcb, PDBj:8bcb
PDBsum8bcb
PubMed36974964
UniProtO75643|U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (Gene Name=SNRNP200)

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