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Structure of PDB 8b9y Chain B Binding Site BS01

Receptor Information
>8b9y Chain B (length=316) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDPRNNVAPSMDALIGETPAVYLKRMNDTAATIVLKLECENPMASVKDRL
AYAIYDKAEKEGKIIPGKSVIVEATSGNTGIALAHIGTIRGYKVIIVMPE
SMSIERRCLMRIFGAEVILTPAALGMKGALEAVNRIVSNNPDAVSANQFA
TKYNAQIHEETTGPEIWRQTKGHVDCFVAGVGTGGTITGVARYLKSVGCG
ATIFAVEPAESPVLSGGKPGPHRIQGIGAGFVPEVFEAALVDEVIQVSGD
EAIDTAQKLPRTDGIFCGFSGGANVYAALQIAKRPEMAGKTIVTVIPSYG
ERYLSTALYVLSAADI
Ligand information
Ligand IDRIB
InChIInChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5+/m1/s1
InChIKeyHMFHBZSHGGEWLO-AIHAYLRMSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@H]([C@H](O1)O)O)O)O
ACDLabs 10.04OC1C(OC(O)C1O)CO
FormulaC5 H10 O5
Namealpha-D-ribofuranose;
alpha-D-ribose;
D-ribose;
ribose
ChEMBLCHEMBL606078
DrugBank
ZINCZINC000003860714
PDB chain8b9y Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8b9y Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		E57 N58 P59 A61
Binding residue
(residue number reindexed from 1)		E40 N41 P42 A44
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
Cellular Component
GO:0005737 cytoplasm

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External links

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