Structure of PDB 8b9y Chain B Binding Site BS01

Receptor Information

>8b9y Chain B (length=316) Species: 5693 (Trypanosoma cruzi)

FDPRNNVAPSMDALIGETPAVYLKRMNDTAATIVLKLECENPMASVKDRL
AYAIYDKAEKEGKIIPGKSVIVEATSGNTGIALAHIGTIRGYKVIIVMPE
SMSIERRCLMRIFGAEVILTPAALGMKGALEAVNRIVSNNPDAVSANQFA
TKYNAQIHEETTGPEIWRQTKGHVDCFVAGVGTGGTITGVARYLKSVGCG
ATIFAVEPAESPVLSGGKPGPHRIQGIGAGFVPEVFEAALVDEVIQVSGD
EAIDTAQKLPRTDGIFCGFSGGANVYAALQIAKRPEMAGKTIVTVIPSYG
ERYLSTALYVLSAADI

Ligand information

• Ligand ID: RIB
• InChI: InChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5+/m1/s1
• InChIKey: HMFHBZSHGGEWLO-AIHAYLRMSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(O1)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@H]([C@H](O1)O)O)O)O
  ACDLabs 10.04: OC1C(OC(O)C1O)CO
• Formula: C5 H10 O5
• Name: alpha-D-ribofuranose;
  alpha-D-ribose;
  D-ribose;
  ribose
• ChEMBL: CHEMBL606078
• ZINC: ZINC000003860714
• PDB chain: 8b9y Chain A Residue 702

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8b9y Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): E57 N58 P59 A61
• Binding residue (residue number reindexed from 1): E40 N41 P42 A44
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8b9y, PDBe:8b9y, PDBj:8b9y
• PDBsum: 8b9y
• PubMed: 37204818
• UniProt: Q4CST7