Structure of PDB 8b8q Chain B Binding Site BS01

Receptor Information
>8b8q Chain B (length=691) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQQDFRTPEFEEFNGKPDSLFFTDGQRRIDFILVYEDESGTNEKQKRKRQ
AYESNLICHGLQLEATRSVSDKLVFVKVHAPWEVLCTYAEIMHIKLPLKS
FFNPATRSRIVYFILSRVINRLVSSGIYKAAFPLHDCRFNYESEDISCPS
ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAA
VVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNIT
CESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQ
TCGKCIRVTLCASAVFFWILLIIASVIGIIVYRLSVFIVMATSITASIIS
HIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSC
FYIAFFKGKFVGYPGDPVYLLGKYRSEECDPGGCLLELTTQLTIIMGGKA
IWNNIQEVLLPWVMNLIGRYKKITPRWEQDYHLQPMGKLGLFYEYLEMII
QFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIG
AWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTM
DGYINNTLSVFNITDENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYW
HVIAAKLAFIIVMEHIIYSVKFFISYAIPDVSKITKSKIKR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8b8q Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8b8q Structural basis for the activation of the lipid scramblase TMEM16F.
Resolution2.94 Å
Binding residue
(original residue number in PDB)		N620 N621 E624 E670 E699
Binding residue
(residue number reindexed from 1)		N453 N454 E457 E497 E526
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0005254 chloride channel activity
GO:0017128 phospholipid scramblase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0006821 chloride transport
GO:0006869 lipid transport
GO:0007596 blood coagulation
GO:0017121 plasma membrane phospholipid scrambling
GO:0030501 positive regulation of bone mineralization
GO:0032060 bleb assembly
GO:0034220 monoatomic ion transmembrane transport
GO:0034767 positive regulation of monoatomic ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035630 bone mineralization involved in bone maturation
GO:0043065 positive regulation of apoptotic process
GO:0045332 phospholipid translocation
GO:0045794 negative regulation of cell volume
GO:0051649 establishment of localization in cell
GO:0060078 regulation of postsynaptic membrane potential
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0061588 calcium activated phospholipid scrambling
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061591 calcium activated galactosylceramide scrambling
GO:0070588 calcium ion transmembrane transport
GO:0090026 positive regulation of monocyte chemotaxis
GO:1902476 chloride transmembrane transport
GO:1903766 positive regulation of potassium ion export across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
GO:0097060 synaptic membrane
GO:0098981 cholinergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b8q, PDBe:8b8q, PDBj:8b8q
PDBsum8b8q
PubMed36335104
UniProtQ6P9J9|ANO6_MOUSE Anoctamin-6 (Gene Name=Ano6)

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