Structure of PDB 8b79 Chain B Binding Site BS01

Receptor Information
>8b79 Chain B (length=1119) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGW
LTNMHATLVSQQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVN
DVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLF
EARKLLRPILQDNANNNVQRNIYNVVDAKHLIEDIREYDVPYHVRVSIDK
DIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQ
IMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVA
LLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPD
AEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPE
LMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDET
LRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGH
VESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKV
TNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQPD
SIKAERDCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSK
KKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQREN
PFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYD
SLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVER
VGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQK
FTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKK
RYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYS
AVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSI
TTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIP
IKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGV
SNPVPRVEHPDWLKRKIAT
Ligand information
Receptor-Ligand Complex Structure
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PDB8b79 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		Q434 D875 T876 K967 Y969 K982 G983 K987 R988 R989 S1051 S1053 Y1059 Q1062
Binding residue
(residue number reindexed from 1)		Q377 D808 T809 K900 Y902 K915 G916 K920 R921 R922 S984 S986 Y992 Q995
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b79, PDBe:8b79, PDBj:8b79
PDBsum8b79
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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