Structure of PDB 8ase Chain B Binding Site BS01

Receptor Information
>8ase Chain B (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHERNIEKISMLEKIYIHPRYNWRENLDRDIALMKL
KKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
QFG
Ligand information
>8ase Chain A (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB8ase Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3
Resolution2.55 Å
Binding residue
(original residue number in PDB)		E23 I24 G25 M26 W29 S48 D49 F114 D116 H119 P120 V121 C122 Y134 K135 G136 R137 N159 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 G10 M11 W14 S34 D35 F106 D108 H111 P112 V113 C114 Y129 K130 G131 R132 N159 K207 P209 N212 R213 W214
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:8ase, PDBe:8ase, PDBj:8ase
PDBsum8ase
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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