Structure of PDB 8aqa Chain B Binding Site BS01

Receptor Information

>8aqa Chain B (length=155) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKRE

Ligand information

>8aqa Chain C (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KGcKK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8aqa Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2260
Resolution	1.35 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 A132 S135 G151 N152 G153 V155 Y161
Binding residue (residue number reindexed from 1)	H35 D113 Y114 A116 S119 G135 N136 G137 V139 Y145

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

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Molecular Function

External links

PDB	RCSB:8aqa, PDBe:8aqa, PDBj:8aqa
PDBsum	8aqa
PubMed	38809037
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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