Structure of PDB 8a9k Chain B Binding Site BS01

Receptor Information
>8a9k Chain B (length=960) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELRE
KLDLQSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDL
VMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMC
SSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHIC
SGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKL
FYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMA
GIMAADRLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKL
DPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEDGIAINL
LPLLFSQDVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLE
PGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRL
KHIVELQIILEKYLAVTPDYVPPLNSHAFFRELDIEVFSILHCGLVTKFI
LVVQLGPPELLFLLEDLSQKLESMLTRNIGFSHLQQRSAQEIVHCVFQLL
TPMCNHLENIHNYFQCLAAKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQP
ENQNLLYSALHVLSSRLKQSQPLEELLSQSVHYLQNFHQSIPSFQCALYL
IRLLMVILEKSTASAQNKEKIASLARQFLCRVWPSNISNDQLHALLCIYL
EHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTFVVFFRVMMA
ELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPV
LHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHH
LCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLK
NRDLQGEEIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8a9k Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		H1288 R1352
Binding residue
(residue number reindexed from 1)		H848 R912
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007129 homologous chromosome pairing at meiosis
GO:0007276 gamete generation
GO:0010332 response to gamma radiation
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0034599 cellular response to oxidative stress
GO:0036297 interstrand cross-link repair
GO:0045589 regulation of regulatory T cell differentiation
GO:0048854 brain morphogenesis
GO:0050727 regulation of inflammatory response
GO:0097150 neuronal stem cell population maintenance
GO:1990918 double-strand break repair involved in meiotic recombination
GO:2000348 regulation of CD40 signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016604 nuclear body
GO:1990391 DNA repair complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a9k, PDBe:8a9k, PDBj:8a9k
PDBsum8a9k
PubMed36170365
UniProtQ9BXW9|FACD2_HUMAN Fanconi anemia group D2 protein (Gene Name=FANCD2)

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