Structure of PDB 8a98 Chain B Binding Site BS01

Receptor Information
>8a98 Chain B (length=402) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARAFPKDDATQKPHLTSFMVFKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVIVGIVGYRQTPVGLKT
IGTVWAHHTSVEFRRRYYKNWKQSAQLAFSRQKQFANTKEGKVAEARTLN
AFAKKASVIRVIAHTQLRKLRNHRVGVKKAHVQEIQVNGGSVAAKIALAK
SLLEKEVRVDSVFQQSEACDVCSVTKGHGTEGVVKRWGVACLPRKTHRGL
RKVACIGAWHPARVMYTVARAGQHGYHHRTQLNKKIYQIGRSVAVEPNQA
TTTYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVSGPRRRVMTLRRPMAP
QTSRQLKEKIVLKFIDTSSKIGHGRFQTKKEKNQWFGPLKKDRIRREERL
RK
Ligand information
>8a98 Chain 1 (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuuaaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaagagccagaaccagcccuacugca
uuauccugucgggggucaaaauccggcgggcaacgaagugcaagaggguc
uuggugaaaugagcggaguauuugagcuggcacgggcacgcacucuucuc
cgugaugcuccauguuggcgauggaaauggggugcccccacccgucuuga
aacacggaccaaggagucaaacagacgcgcaagggaggagauauggccag
uacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcac
acgucaaauccguuugauuugcccaacaccgaccggcccuccguggguug
cguuggagugugccuguuuggacccgaaagguggugaacuaugccugaac
aaggugaagcccggggaaacccagguggaggccuguagcgaugcugacgu
gcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaacca
ccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuagu
agaaguauugugcgguaaagcgauacuuuaaaugugcaaacaaaccggcc
uuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggc
cuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauau
guggcgucaaaacuuaugggcucauucucgauacguaaaggguguuggug
gccaccggccccgaaaauggaugacgcuuaaggccaauuagugaaugccc
auuauuccuuugguaagggcggaaacggagaaaguguagcccuuccgaug
uagauguggccuggagguuaggacgaagcuuauggcgugagccuaagaug
gaccggccucuagugcagaucuugguuggcguagcaaagaucuaacggag
auauacucaacaugcaacguuggauacuggagcggggaaggauuucgugc
caacggcacucguacacgaguuguucggaaacugagcacaacguuauauc
guuuuguuaggaaagugaaguacugaaaaggggcaacagagaaccuggga
uuauauuccaaaaagaaauugcauguggg
......................<<<<<......<<....>>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<.<<<<<......>>>>>..>....>>>>>
..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......(((..<<<<<<.<<<<<.....<<<<<.<<<<<<<<<...<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>...>>>>>.
.>>>>........<<<<<.....<<....<<.<..>...>>..>>..>>>
>>.....<<<<...>>>>>.....>>>>>>>>>>>..))).<<<<.....
...>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........
.>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<
<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>
.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.
.<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<...
.....>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>
>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<...
..<<...<<<<<<<...<<<.....>>.>...>>>>>>>.....<<<<<<
<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<
<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<.
..<<<<<<......[..((.(........(.........<<<.<<<<<<<
..>>>>>>>>>>..........>>>.)....).)).].........>>>.
..>>>>>>>((((.<<<<<.......>>>>.........>>>>>))))..
..>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.
....>>>>>>>>..>.....>>>>>>..............<<<<<<<...
.................>>>>>>>....................<<<<<.
...<<.....>>..>>>>>....<<..........<<.<<<<<......>
>>>...............<....>......>.>>..........<<<<..
.......>>....>>.>>...........
Receptor-Ligand Complex Structure
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PDB8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution2.46 Å
Binding residue
(original residue number in PDB)		K246 H248
Binding residue
(residue number reindexed from 1)		K245 H247
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum8a98
PubMed38722744
UniProtQ4Q2Q6

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