Structure of PDB 8a8u Chain B Binding Site BS01

Receptor Information
>8a8u Chain B (length=568) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGE
PGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEE
RLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGEL
QTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYE
AHHRVSITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMVA
EVDDEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKA
VSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDAL
IQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEI
EKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLYERMKQKVN
DELKKHFRPEFLNRIDDIIVFHQLTREEIIRMVDLMISRVAGQLKSKDMA
LVLTDAAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQ
VVTVDVDNWDEDAVFTFT
Ligand information
>8a8u Chain G (length=23) Species: 1773 (Mycobacterium tuberculosis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAGAAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
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PDB8a8u Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
Resolution3.62 Å
Binding residue
(original residue number in PDB)		Y261 R262 A298 G600 Y601 V602
Binding residue
(residue number reindexed from 1)		Y94 R95 A131 G373 Y374 V375
Enzymatic activity
Enzyme Commision number 3.4.-.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042803 protein homodimerization activity
GO:0044183 protein folding chaperone
Biological Process
GO:0006457 protein folding
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a8u, PDBe:8a8u, PDBj:8a8u
PDBsum8a8u
PubMed36208775
UniProtP9WPC9|CLPC1_MYCTU ATP-dependent Clp protease ATP-binding subunit ClpC1 (Gene Name=clpC1)

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