Structure of PDB 8a11 Chain B Binding Site BS01

Receptor Information
>8a11 Chain B (length=470) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLE
ALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGV
NVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISAT
SIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYAR
LRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCR
AGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVA
VALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDL
RSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGL
LEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQA
LREEVESFASLFPLPGLPDF
Ligand information
Receptor-Ligand Complex Structure
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PDB8a11 Cryo-EM structure of the Human SHMT1-RNA complex
Resolution3.52 Å
Binding residue
(original residue number in PDB)		R393 S394 A395
Binding residue
(residue number reindexed from 1)		R380 S381 A382
Enzymatic activity
Enzyme Commision number 2.1.2.1: glycine hydroxymethyltransferase.
Gene Ontology
Molecular Function
GO:0000900 mRNA regulatory element binding translation repressor activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016832 aldehyde-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0048027 mRNA 5'-UTR binding
GO:0070905 serine binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0017148 negative regulation of translation
GO:0019264 glycine biosynthetic process from serine
GO:0035999 tetrahydrofolate interconversion
GO:0045329 carnitine biosynthetic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process
GO:0051289 protein homotetramerization
GO:1904482 cellular response to tetrahydrofolate
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a11, PDBe:8a11, PDBj:8a11
PDBsum8a11
PubMed38996576
UniProtP34896|GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic (Gene Name=SHMT1)

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